Blastocyst not implant for multiple reasons, including (but not limited to) poor egg/sperm quality, abnormal embryonic chromosomes, an unhealthy uterine lining, smoking, stress and other psychological factors. Multiple IVF cycle failures are not guaranteed. Many patients who have implantation failure are able to have children with the help of an experienced physician.
While there are many steps to the In Vitro Fertilization (IVF) process, one of the most interesting and emotionally taxing parts for patients is blastocyst culture in Jaipur. During this process, embryologists grow patient eggs for five to six days prior to transfer. Blastocysts are more developed than earlier stage embryos and are therefore better assessed for quality. While there are many potential reasons that blastocysts may not implant, this is known as implantation failure. Sometimes this happens only once during an IVF process and other times this recurrent implantation failure occurs many times over. Regardless, implantation failure can be emotionally draining and taxing for many patients.
It is our hope that this information is useful in your search for answers and brings you a step closer to your goal of creating and growing your family.
Why Blastocyst Not Implant?
Implantation of a Blastocyst requires a series of interactions and events between the Blastocyst and the lining of the uterus (the endometrium). When one or more of these interactions doesn’t happen, implantation won’t occur. Below are the reasons in order of frequency as observed by the author.
1. Poor Quality of the Egg and Sperm
The overall quality of the embryo is a reflection of the egg and sperm that created it. Genetic issues in the egg or sperm can decrease the likelihood of implantation. If there is an embryonic formation and implantation, it can lead to pregnancy loss. One of the reasons that IVF clinics perform fertility and genetic testing to the prospective parents is to help determine the reason for the embryo implantation and pregnancy loss.
2. Chromosomal Issues
Chromosomal abnormalities can occur even when the structure and organization of the cell is ideal. The absence of normal chromosome number can result in an embryo that is incapable of implantation and can lead to pregnancy loss. Preimplantation genetic testing of the embryo (PGT) helps in evaluating chromosome number of the embryo prior to embryo transfer to increase the chance of normal pregnancy.
3. Issues with the Uterus
The lining of the uterus is prepared to receive the embryo during a specific time frame, if it is not during that time, the embryo can not implant. The lining of the uterus can be affected by fibroids, scar tissue, polyps and inflammation. In the presence of all these conditions, the embryo can not attach to the uterine wall. Hormonal imbalance, most commonly insufficient progesterone, can affect the lining of the uterus during implantation.
4. Lifestyle Factors
Certain lifestyle choices can adversely affect the reproductive system. Some of these choices are poor nutrition, heavy alcohol consumption, stress and obesity. Some studies show that regular smoking and second-hand smoking can adversely affect uterine blood flow. This can make the endometrium less receptive. All of the above-mentioned factors can hinder the implantation of even a healthy embryo.
What Are the Symptoms of a Fertilized Egg Not Implanting?
Many patients who are undergoing assisted reproduction techniques get frustrated because they are unable to identify the reasons for the blastocyst not implant. There are a few indicators which may suggest that the embryo has not implanted. These indicators may include:
- Resumption of menses
- Thermal shift (Basal body temperature) in the anticipated window of implantation
- Negative serum or urine pregnancy tests in the window of 14-16 days
- Absence of clinical symptoms of pregnancy
The above mentioned indicators may also occur in a normal menstrual cycle. Hormone levels may be measured to confirm implantation.
How Is Implantation Failure During Blastocyst Transfer Treated?
The treatment of implantation failure is dependent on identification of the cause of the failure. Some of the treatments include:
- Use of hormones to alter the endometrial lining in preparation for implantation.
- Surgical removal of polyps and fibroids.
- Preimplantation Genetic Testing (PGT): Embryos that have been biopsied and tested to rule out chromosomal abnormalities have a higher implantation rate.
- Immunological Treatment: Some cases may require additional treatment in order to bypass immune-related barriers to embryo implantation.
What Else Can Be Done To Improve The Success Of Your Embryo Transfer?
Even though most factors that impact embryo implantation are out of a patient’s control, there are a few things that can increase the chances of a successful embryo transfer.
- Choose the Right Fertility Clinic: The impact of the team and the clinic on the embryo transfer and blastocyst culture outcome is significant.
- Healthy Embryo Implantation: Making healthy lifestyle changes can improve the chances of a healthy embryo implantation.
- Ask About Genetic Testing: Patients who have repeated implantation failures or repeated pregnancy losses may benefit from genetic testing to identify the best embryo to implant.
- Post Embryo Transfer: It is important to follow the instructions given by your healthcare provider and limit your activities to give the best opportunity for the embryo to implant.
Prior to embryo transfer, evaluation of your uterus may help identify any abnormalities or issues that may impact the success of embryo implantation.
If Blastocyst culture and transfer is being considered, there are many clinics in Jaipur that combine advanced embryology and exceptional patient care.
Moving on After Blastocyst Not Implant
A blastocyst that does not implant is failure is disheartening. However, it is not the end of the road. The cause of failure may be due to poor embryo quality, lack of uterine receptivity or other factors beyond the embryo. Once the cause is identified, your next step will be addressed accordingly.
Dr. Sapna Basandani at Anmol Fertility Center prides herself on taking the extra step to figure out the cause of failure with her patients. She develops a plan that is unique and specific to each patient for the next embryo transfer. If you are considering the Best IVF Doctor in Jaipur or the Best IVF Center in Jaipur, schedule a consultation for your implantation failure case and other cases at no additional cost.
Frequently Asked Questions
What is implantation failure?
There are many reasons that implantation failure may occur. Some reasons include deficiency in the endometrial lining, patient immune status, embryonic factor, endometrial receptivity, sub-microscopic uterine disorders and others.
Is there hope after implantation failure?
Yes, although you have experienced failure with previous IVF cycles, it does not mean you will experience failure with future IVF cycles.
What tests are conducted to investigate cases of implantation failure?
Some of the tests are endometrial receptivity analysis, hysteroscopy, hormonal tests, and preimplantation genetic testing (PGT) of the embryo.
When should a case of implantation failure warrant a visit to a fertility specialist?
A fertility specialist should be consulted if there is more than one case of embryo transfer failure, especially in cases where the embryos transferred were good quality blastocysts.